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1

How enzymes adapt: lessons from directed evolution

Frances H Arnold, Patrick L Wintrode, Kentaro Miyazaki, Anne Gershenson

Journal:

Trends in Biochemical Sciences

Year:

2001

Language:

english

File:

PDF, 183 KB

english, 2001

2

Thermodynamics of ubiquitin unfolding

Patrick L. Wintrode, George I. Makhatadze, Dr. Peter L. Privalov

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1994

Language:

english

File:

PDF, 606 KB

english, 1994

3

[Advances in Protein Chemistry] Evolutionary Protein Design Volume 55 || Temperature adaptation of enzymes: Lessons from laboratory evolution

Wintrode, Patrick L.

Year:

2001

Language:

english

File:

PDF, 3.55 MB

english, 2001

4

Effects of glycosylation on the stability and flexibility of a metastable protein: The human serpin α1-antitrypsin

Anindya Sarkar, Patrick L. Wintrode

Journal:

International Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 581 KB

english, 2011

5

Structural energetics of barstar studied by differential scanning microcalorimetry

Patrick L. Wintrode, Yuri V. Griko, Peter L. Privalov

Journal:

Protein Science

Year:

1995

Language:

english

File:

PDF, 617 KB

english, 1995

6

Complementary Structural Mass Spectrometry Techniques Reveal Local Dynamics in Functionally Important Regions of a Metastable Serpin

Xiaojing Zheng, Patrick L. Wintrode, Mark R. Chance

Journal:

Year:

2008

Language:

english

File:

PDF, 2.32 MB

english, 2008

7

Patterns of adaptation in a laboratory evolved thermophilic enzyme

Patrick L Wintrode, Kentaro Miyazaki, Frances H Arnold

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2001

Language:

english

File:

PDF, 369 KB

english, 2001

8

Energetics of target peptide recognition by calmodulin: A calorimetric study

Patrick L. Wintrode, Peter L. Privalov

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 958 KB

english, 1997

9

Directed evolution study of temperature adaptation in a psychrophilic enzyme

Kentaro Miyazaki, Patrick L Wintrode, Rowan A Grayling, Donn N Rubingh, Frances H Arnold

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 359 KB

english, 2000

10

Multi-state Unfolding of the Alpha Subunit of Tryptophan Synthase, a TIM Barrel Protein: Insights into the Secondary Structure of the Stable Equilibrium Intermediates by Hydrogen Exchange Mass Spectrometry

Teerapat Rojsajjakul, Patrick Wintrode, Ramakrishna Vadrevu, C. Robert Matthews, David L. Smith

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 368 KB

english, 2004

11

An Obligatory Intermediate Controls the Folding of the α-Subunit of Tryptophan Synthase, a TIM Barrel Protein

Patrick L. Wintrode, Teerapat Rojsajjakul, Ramakrishna Vadrevu, C. Robert Matthews, David L. Smith

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 305 KB

english, 2005

12

Cooperative Unfolding of a Metastable Serpin to a Molten Globule Suggests a Link Between Functional and Folding Energy Landscapes

Yuko Tsutsui, Patrick L. Wintrode

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.44 MB

english, 2007

13

Identification of a Region in the N-Terminus of Escherichia coli Lon That Affects ATPase, Substrate Translocation and Proteolytic Activity

Iteen Cheng, Natalie Mikita, Jennifer Fishovitz, Hilary Frase, Patrick Wintrode, Irene Lee

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

14

Protein Dynamics in a Family of Laboratory Evolved Thermophilic Enzymes

Patrick L Wintrode, Deqiang Zhang, Nagarajan Vaidehi, Frances H Arnold, William A Goddard III

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.80 MB

english, 2003

15

Folding Mechanism Of The Z Mutant Of Human Antitrypsin Studied By H/D Exchange

Sengupta, Tanusree, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

16

Conformational Dynamics of Antithrombin III With its Allosteric Activator Heparin

Boucher, Lauren, de la Cruz, Richard, Bock, Susan, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

17

Allosteric Suppression of HIV-1 Reverse Transcriptase Structural Dynamics upon Inhibitor Binding

Seckler, James M., Barkley, Mary D., Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 1.03 MB

english, 2011

18

Native State Dynamics of Human Neuroserpin Investigated with Hydrogen/Deuterium Exchange and Molecular Dynamics Simulations

Zhou, Crystal, Sarkar, Anindya, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 59 KB

english, 2011

19

Local Conformational Flexibility Provides a Basis for Facile Polymer Formation in Human Neuroserpin

Sarkar, Anindya, Zhou, Crystal, Meklemburg, Robert, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 827 KB

english, 2011

20

Conformational Flexibility Mediates Resistance of HIV-1 Reverse Transcriptase to Nonucleoside Inhibitors

Deredge, Daniel, Venencia, Carl, Howard, Kathryn, Barkley, Mary D., Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 34 KB

english, 2012

21

HIV-1 Reverse Transcriptase Monomers Adopt Multiple Conformations in Solution

Seckler, James M., Trewhella, Jill, Barkley, Mary D., Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

22

Anchoring of PI-PLC to DMPC Bilayers Involves Specific Cation-PI Interactions

Grauffel, Cédric, He, Tao, Yang, Bo-qian, Guo, Su, Wintrode, Patrick L., Gershenson, Anne, Roberts, Mary F., Reuter, Nathalie

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

23

Early Hydrophobic Collapse of α1-Antitrypsin Facilitates Formation of a Metastable State: Insights from Oxidative Labeling and Mass Spectrometry

Bradley B. Stocks, Anindya Sarkar, Patrick L. Wintrode, Lars Konermann

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.34 MB

english, 2012

24

Does Changing the Predicted Dynamics of a Phospholipase C Alter Activity and Membrane Binding?

Cheng, Jiongjia, Karri, Sashank, Grauffel, Cédric, Wang, Fang, Reuter, Nathalie, Roberts, Mary F., Wintrode, Patrick L., Gershenson, Anne

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 1.25 MB

english, 2013

25

Efavirenz Binding Site in HIV-1 Reverse Transcriptase Monomers

Braz, Valerie A., Barkley, Mary D., Jockusch, Rebecca A., Wintrode, Patrick L.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.41 MB

english, 2010

26

Solution Structure and Dynamics of a Heat Shock Protein Assembly Probed by Hydrogen Exchange and Mass Spectrometry †

Wintrode, Patrick L., Friedrich, Kenneth L., Vierling, Elizabeth, Smith, Jean B., Smith, David L.

Journal:

Year:

2003

Language:

english

File:

PDF, 296 KB

english, 2003

27

Molecular Origins of HIV-1 reverse Transcriptase Resistance to Efavirenz

Deredge, Daniel J., Howard, Kathryn J., Seckler, James M., Barkley, Mary D., Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

28

H/D Exchange Provides Insights Into The Orientation Of Bacillus Thuringiensis Pi-phospholipase C Binding To Mixed Component Vesicles

Shi, Xiaomeng, Roberts, Mary F., Meklemburg, Robert, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 39 KB

english, 2009

29

Structural Changes in Monomeric HIV-RT Upon Binding the NNRTI Efavirenz

Braz, Valerie A., Wintrode, Patrick L., Barkley, Mary D.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

30

THE FEVER NURSE

Sarkar, Anindya, Zhou, Crystal, Wintrode, Patrick L.

Journal:

Year:

1954

Language:

english

File:

PDF, 186 KB

english, 1954

31

Is the Serpin Folding Mechanism Conserved? The Folding Pathways of Human Alpha-1 Antitrypsin and Neuroserpin

Sarkar, Anindya, Zhou, Crystal, Wintrode, Patrick L.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

32

Cation-PI Interactions as Specific Anchors for B. Thurigiensis Phosphoinositol-Specific Phospholipase-C Binding to Phosphatidylcholine Bilayer

Grauffel, Cédric, He, Tao, Yang, Boqian, Wintrode, Patrick L., Gershenson, Anne, Roberts, Mary F., Reuter, Nathalie

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 38 KB

english, 2013

33

Mass spectrometry in structural biology

Wintrode, Patrick

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 115 KB

english, 2013

34

Different Properties of the Native and Reconstituted Heterotrimeric G Protein Transducin †

Goc, Anna, Angel, Thomas E., Jastrzebska, Beata, Wang, Benlian, Wintrode, Patrick L., Palczewski, Krzysztof

Journal:

Year:

2008

Language:

english

File:

PDF, 491 KB

english, 2008

35

The Conformational Dynamics of a Metastable Serpin Studied by Hydrogen Exchange and Mass Spectrometry

Tsutsui, Yuko, Liu, Lu, Gershenson, Anne, Wintrode, Patrick L.

Journal:

Year:

2006

Language:

english

File:

PDF, 549 KB

english, 2006

36

Local and Global Effects of a Cavity Filling Mutation in a Metastable Serpin

Sengupta, Tanusree, Tsutsui, Yuko, Wintrode, Patrick L.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.70 MB

english, 2009

37

Correction to Solution Structural Dynamics of HIV-1 Reverse Transcriptase Heterodimer

Seckler, James M., Howard, Kathryn J., Barkley, Mary D., Wintrode, Patrick L.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.16 MB

english, 2010

38

Solution Structural Dynamics of HIV-1 Reverse Transcriptase Heterodimer

Seckler, James M., Howard, Kathryn J., Barkley, Mary D., Wintrode, Patrick L.

Journal:

Year:

2009

Language:

english

File:

PDF, 4.71 MB

english, 2009

39

A Dimer Interface Mutation in Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Its Binding to AU-rich RNA

White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 4.62 MB

english, 2015

40

A dimer interface mutation in glyceraldehyde 3-phosphate dehydrogenase regulates its binding to AU-rich RNA.:

White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 799 KB

english, 2015

41

Hydrogen/Deuterium Exchange-Mass Spectrometry: A Powerful Tool for Probing Protein Structure, Dynamics and Interactions

Tsutsui, Yuko, Wintrode, Patrick

Journal:

Current Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 752 KB

english, 2007

42

Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase

Deredge, Daniel J., Johnson, Kenneth, Wintrode, Patrick

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 46 KB

english, 2015

43

Enhanced Molecular Mobility of Ordinarily Structured Regions Drives Polyglutamine Disease

Lupton, Christopher J., Steer, David L., Wintrode, Patrick L., Bottomley, Stephen P., Hughes, Victoria A., Ellisdon, Andrew M.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.78 MB

english, 2015

44

Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase

Deredge, Daniel, Li, Jiawen, Johnson, Kenneth A., Wintrode, Patrick L.

Journal:

Journal of Biological Chemistry

Year:

2016

File:

PDF, 2.69 MB

2016

45

Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase

Deredge, Daniel, Li, Jiawen, Johnson, Kenneth A., Wintrode, Patrick L.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.69 MB

english, 2016

46

Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-Dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation

Li, Jiawen, Deredge, Daniel, Wintrode, Patrick L., Johnson, Kenneth A.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

47

Ligand Induced Allostery in Pseudomonas Aeruginosa Cytoplasmic Heme Binding Protein (Phus) Drives the Protein-Protein Interaction with Heme Oxygenase

Deredge, Daniel J., Huang, Weiliang, Hui, Colleen, Moenne-Loccoz, Pierre, Wilks, Angela, Wintrode, Patrick

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 44 KB

english, 2016

48

Dynamics of Glyceraldehyde-3-Phosphate Dehydrogenase Interfacial Regions Affect Binding to AU-Rich RNA

White, Michael, Khan, Mohsin, Deredge, Daniel, Ross, Christina, Quintyn, Royston, Zucconi, Beth, Wysocki, Vicki, Wintrode, Patrick, Wilson, Gerald, Garcin, Elsa

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 41 KB

english, 2015

49

Simulating the Serpin Latency Transition at Atomic Resolution

Wintrode, Patrick, Faccioli, Pietro, Beccara, Silvio a, Gershenson, Anne, Cazzolli, Giorgia, Wang, Fang

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 40 KB

english, 2015

50

Folding Mechanism of a Metastable Serpin at Atomic Resolution

Wang, Fang, Ke, Haiping, Beccara, Silvio a, Gershenson, Anne, Faccioli, Pietro, Wintrode, Patrick

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 46 KB

english, 2016